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hydrophobic environment triggering reactive fluorescence probe to real-time monitor mitochondrial DNAdamage

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 92-102 doi: 10.1007/s11705-021-2063-9

Abstract: Mitochondrial DNA has a special structure that is prone to damage resulting in many serious diseases,Therefore, the rapid and specific monitoring of mitochondrial DNA damage is urgently needed for biologicalIn this design, MBI-CN conjugates to mitochondrial DNA without causing additional damages.DNA damage.damage during cell apoptosis and initial assessment of cell apoptosis.

Keywords： hydrolysis reaction     mitochondrial DNA damage     in situ hydrophobic environment trigger     fluorescence    

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Non-genetic mechanisms of diabetic nephropathy

Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 319-332 doi: 10.1007/s11684-017-0569-9

Abstract: the aspects of immune inflammation response, epithelial–mesenchymal transition, apoptosis and mitochondrialdamage, epigenetics, and podocyte–endothelial communication.

Keywords： diabetic nephropathy     immune inflammatory response     epithelial–mesenchymal transition     apoptosis     mitochondrialdamage     epigenetics     podocyte–endothelial communication    

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Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 216-226 doi: 10.1007/s11684-022-0920-7

Abstract: Hepatocellular carcinoma (HCC), which makes up the majority of liver cancer, is induced by the infection of hepatitis B/C virus. Biomarkers are needed to facilitate the early detection of HCC, which is often diagnosed too late for effective therapy. The tRNA-derived small RNAs (tsRNAs) play vital roles in tumorigenesis and are stable in circulation. However, the diagnostic values and biological functions of circulating tsRNAs, especially for HCC, are still unknown. In this study, we first utilized RNA sequencing followed by quantitative reverse-transcription PCR to analyze tsRNA signatures in HCC serum. We identified tRF-Gln-TTG-006, which was remarkably upregulated in HCC serum (training cohort: 24 HCC patients vs. 24 healthy controls). In the validation stage, we found that tRF-Gln-TTG-006 signature could distinguish HCC cases from healthy subjects with high sensitivity (80.4%) and specificity (79.4%) even in the early stage (Stage I: sensitivity, 79.0%; specificity, 74.8%; 155 healthy controls vs. 153 HCC patients from two cohorts). Moreover, in vitro studies indicated that circulating tRF-Gln-TTG-006 was released from tumor cells, and its biological function was predicted by bioinformatics assay and validated by colony formation and apoptosis assays. In summary, our study demonstrated that serum tsRNA signature may serve as a novel biomarker of HCC.

Keywords： tsRNA     biomarker     hepatocarcinoma    

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Conserved gene arrangement in the mitochondrial genomes of barklouse families Stenopsocidae and Psocidae

Xiaochen LIU, Hu LI, Yao CAI, Fan SONG, John-James WILSON, Wanzhi CAI

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 358-365 doi: 10.15302/J-FASE-2017158

Abstract: Substantial variation in gene organization and arrangement has been reported for sequenced mitochondrial

Keywords： gene rearrangement     mitochondrial genome     Psocoptera     Stenopsocidae     TDRL model    

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N-Positive ion activated rapid addition and mitochondrial targeting ratiometric fluorescent probes

Yan Shi, Fangjun Huo, Yongkang Yue, Caixia Yin

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 64-71 doi: 10.1007/s11705-021-2048-8

Abstract: In addition, cell imaging shows that this probe can be used for the mitochondrial targeted detection

Keywords： heterocyclic compound     hydrogen sulfide     ratiometric     mitochondrial targeted    

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Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission

Frontiers of Medicine doi: 10.1007/s11684-023-0983-0

Abstract: Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission

Keywords： mitochondrial fission Ca     Berberine alleviates myocardial     murine model HFpEF    

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NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients

Ya-Song WU MD, PhD, Xin-Yue CHEN MD, Ying SHI PhD, Hao WU MD, De-Xi CHEN MD, PhD, Yu SUN MD, Fu-Jie ZHANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 177-184 doi: 10.1007/s11684-010-0038-1

Abstract: Nucleoside reverse transcriptase inhibitors (NRTIs) could damage the mitochondria by inhibiting the humanDirect DNA-sequencing analysis techniques were used to detect mitochondrial sequence variants between

Keywords： nucleoside reverse transcriptase inhibitors     human immunodeficiency virus     mitochondrial DNA     D loop     mutation    

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Association of gene variants with juvenile amyotrophic lateral sclerosis

Frontiers of Medicine doi: 10.1007/s11684-023-1005-y

Abstract: A decreased number of mitochondria, swollen mitochondria, lower expression of ND1, decreased mitochondrialcomplex I activities, lower mitochondrial aerobic respiration, and a high level of ROS were observed

Keywords： TRMT2B     amyotrophic lateral sclerosis     mitochondrial complex I     tRNA methylation     reactive oxygen    

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Windborne debris damage prediction analysis

Fangfang SONG, Jinping OU,

Frontiers of Structural and Civil Engineering 2010, Volume 4, Issue 3,   Pages 326-330 doi: 10.1007/s11709-010-0067-5

Abstract: Windborne debris is one of the most important causes of the envelop destruction according to the post-damageThe problem of windborne debris damage could be summarized as three parts, including windborne debrisBesides, the process of windborne debris damage analysis is described in detail.

Keywords： typhoon     windborne debris     structural envelopes     damage estimation    

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Corrosion damage assessment and monitoring of large steel space structures

Bo CHEN, You-Lin XU, Weilian QU,

Frontiers of Structural and Civil Engineering 2010, Volume 4, Issue 3,   Pages 354-369 doi: 10.1007/s11709-010-0088-0

Abstract: This paper proposes a framework for assessing the corrosion damage of large steel space structures subjectedreal large steel space structure built in the southern coastal area in China to assess its corrosion damage

Keywords： large steel space structure     atmospheric corrosion     stress corrosion cracking     corrosion damage     damage assessment    

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Detection of damage locations and damage steps in pile foundations using acoustic emissions with deep

Alipujiang JIERULA, Tae-Min OH, Shuhong WANG, Joon-Hyun LEE, Hyunwoo KIM, Jong-Won LEE

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 2,   Pages 318-332 doi: 10.1007/s11709-021-0715-y

Abstract: The aim of this study is to propose a new detection method for determining the damage locations in pileFirst, the damage location is simulated using a back propagation neural network deep learning model withIn particular, the damage location is identified using two parameters: the pile location ( ) and theSecond, the damage step condition is determined using a classification model with an acoustic emissionFinally, a new damage detection and evaluation method for pile foundations is proposed.

Keywords： pile foundations     damage location     acoustic emission     deep learning     damage step    

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Creep life assessment of aero-engine recuperator based on continuum damage mechanics approach

Frontiers of Mechanical Engineering 2022, Volume 17, Issue 4, doi: 10.1007/s11465-022-0702-6

Abstract: The creep life of an aeroengine recuperator is investigated in terms of continuum damage mechanics by

Keywords： creep     life assessment     brazed joint     continuum damage mechanics     aeroengine recuperator    

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Bacterial inactivation, DNA damage, and faster ATP degradation induced by ultraviolet disinfection

Chao Yang, Wenjun Sun, Xiuwei Ao

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 1, doi: 10.1007/s11783-019-1192-6

Abstract: • Long amplicon is more effective to test DNA damage induced by UV. • ATP in bacteria does not degradeWe used quantitative polymerase chain reaction (qPCR) to investigate DNA damage and evaluated adenosineThe results of qPCR effectively showed the DNA damage induced by UV when using longer gene amplicons,

Keywords： UV disinfection     DNA damage     qPCR     ATP    

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The damage evolution behavior of polypropylene fiber reinforced concrete subjected to sulfate attack

Ninghui LIANG; Jinwang MAO; Ru YAN; Xinrong LIU; Xiaohan ZHOU

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 3,   Pages 316-328 doi: 10.1007/s11709-022-0810-8

Abstract: To study the damage evolution behavior of polypropylene fiber reinforced concrete (PFRC) subjected toeffect of sulfate attack relative to time and fiber hybridization were analyzed and the compression damageThe initial damage factor of hybrid PFRC was −0.042 and −0.056 respectively after 150 d of corrosion,

Keywords： polypropylene fiber reinforced concrete     sulfate attack     damage evolution behavior     acoustic emission     damage factor    

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Spectral element modeling based structure piezoelectric impedance computation and damage identification

Zhigang GUO, Zhi SUN

Frontiers of Structural and Civil Engineering 2011, Volume 5, Issue 4,   Pages 458-464 doi: 10.1007/s11709-011-0133-7

Abstract: paper presents a numerical simulation study on electromechanical impedance technique for structural damageThe basic principle of impedance based damage detection is structural impedance will vary with the occurrenceand development of structural damage, which can be measured from electromechanical admittance curvesTherefore, structure damage can be identified from the electromechanical admittance measurements.In this study, a model based method that can identify both location and severity of structural damage

Keywords： PZT     piezoelectric impedance     optimization     spectral element     damage identification    

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Title Author Date Type Operation

hydrophobic environment triggering reactive fluorescence probe to real-time monitor mitochondrial DNAdamage

Journal Article

Non-genetic mechanisms of diabetic nephropathy

Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu

Journal Article

Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis

Journal Article

Conserved gene arrangement in the mitochondrial genomes of barklouse families Stenopsocidae and Psocidae

Xiaochen LIU, Hu LI, Yao CAI, Fan SONG, John-James WILSON, Wanzhi CAI

Journal Article

N-Positive ion activated rapid addition and mitochondrial targeting ratiometric fluorescent probes

Yan Shi, Fangjun Huo, Yongkang Yue, Caixia Yin

Journal Article

Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission

Journal Article

NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients

Ya-Song WU MD, PhD, Xin-Yue CHEN MD, Ying SHI PhD, Hao WU MD, De-Xi CHEN MD, PhD, Yu SUN MD, Fu-Jie ZHANG MD,

Journal Article

Association of gene variants with juvenile amyotrophic lateral sclerosis

Journal Article

Windborne debris damage prediction analysis

Fangfang SONG, Jinping OU,

Journal Article

Corrosion damage assessment and monitoring of large steel space structures

Bo CHEN, You-Lin XU, Weilian QU,

Journal Article

Detection of damage locations and damage steps in pile foundations using acoustic emissions with deep

Alipujiang JIERULA, Tae-Min OH, Shuhong WANG, Joon-Hyun LEE, Hyunwoo KIM, Jong-Won LEE

Journal Article

Creep life assessment of aero-engine recuperator based on continuum damage mechanics approach

Journal Article

Bacterial inactivation, DNA damage, and faster ATP degradation induced by ultraviolet disinfection

Chao Yang, Wenjun Sun, Xiuwei Ao

Journal Article

The damage evolution behavior of polypropylene fiber reinforced concrete subjected to sulfate attack

Ninghui LIANG; Jinwang MAO; Ru YAN; Xinrong LIU; Xiaohan ZHOU

Journal Article

Spectral element modeling based structure piezoelectric impedance computation and damage identification

Zhigang GUO, Zhi SUN

Journal Article